Precision Hepatocellular Carcinoma Treatment Using Synthetic Lethality (Old ID 27904)
Role
Chief Investigator
Description
Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality. Current therapies for HCC show little efficacy due to extensive heterogeneity in the disease and a lack of corresponding patient-tailored treatment options. The purpose of this project is to validate various bioinformatic approaches to identifying personalised cancer driver genes and methods of targeting them through synthetic lethality. An integrated pipeline will be developed for the simple identification of therapeutics from sequencing of tissue biopsies. Finally, patient-derived organoids matched with patient-specific sequencing information will be used to validate this pipeline, building an important foundation for the future of personalised treatment.
Date
01 Mar 2023 - 28 Jun 2024
Project Type
SCHOLARSHIP
Keywords
Liver Cancer;Genetics;Synthetic Lethality;Bioinformatics;Precision Medicine
Funding Body
Tour de Cure
Amount
10000
Project Team
Ulf Schmitz;Matt Field;Lionel Hebbard